Job Description

Description The Principal Scientist will possess an in-depth knowledge of process chemistry skills for the development of synthetic routes for drug substances. The candidate will perform multi-step chemical syntheses and product isolation/purification operations in the laboratory either independently or as part of a project team. The candidate will ensure excellence of our process development and technical transfer to Phlow's partners or customers. The candidate will personify Phlow's shared values and culture, both internally and externally. The candidate will work with the highest standards of safety, integrity, transparency, and ethics to create win-win scenarios for patients, customers, and partners. Responsibilities Provide process chemistry support to Phlow's Continuous Manufacturing R&D lab to ensure deliverables to customer's projects are met on time and on budget. Independently design, synthesize, purify, and analyze chemical intermediates, target compounds, and impurities. Maintain accurate, legible, and complete records of all experiments and observations. Author progress reports and present scientific results to team members. Exhibit a high level of safety awareness and conduct lab operations safely. Contribute to the timely and accurate preparation of regulatory submissions. Participate in ongoing continuous improvements in manufacturing processes to enhance product quality, robustness, and cost-effectiveness. Collaborate with Analytical Chemistry, EHS, Engineering, Project Management, Quality Assurance, and Regulatory Affairs to ensure strong working relationships with all partners and Phlow employees. Requirements Preferred Qualifications Ph.D. with at least 3 years of experience, M.S. with at least 7 years, or B.S. with at least 10 years of experience in Organic Chemistry, Pharmaceutical Sciences, or related fields. Experience in process chemistry and API manufacturing on multi-kilogram scales. Knowledge of ICH and cGMP requirements. Experience working for CROs/CMOs/CDMOs is a plus. Experience with technical and operational risk assessments (e.g., process robustness, mutagenic impurities, nitrosamines). Experience with design of experiments (DOE) and multivariate experimentation approaches. Experience with continuous flow manufacturing process development and implementation. Physical Requirements Constantly required to use computer screens and monitors for reading, writing, presenting, and communicating. Frequently required to talk or hear for communication purposes. Frequently required to reach with arms and hands, perform repetitive motions, and use finger dexterity for computer work. Frequently required to sit; occasionally stand or walk in an office environment. Occasionally lift and/or move up to 10 pounds. To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made for individuals with disabilities. #J-18808-Ljbffr Phlow

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